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Journal of Neurology

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AUG 17, 2026 · JOURNAL ARTICLE

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

Journal of Neurology

Retrospective multicenter study identifying modifiable causes in breakthrough stroke despite anticoagulation, with adjusted hazard ratios for recurrence and myocardial infarction, but limited by observational design and surrogate clinical outcomes rather than definitive practice-changing evidence.

PromisingFrancesca Gabriele Cardiac Tumors and Thrombi Raffaele Ornello

Reported

Sample size1649

Median age80.4 years

Female proportion52.2%

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