SEP 1, 2026 · JOURNAL ARTICLE
Computed tomography–guided precision biopsy combined with metagenomic next-generation sequencing for etiological diagnosis in patients with blood culture-negative systemic infections
Journal of International Medical Research
A single-center retrospective cohort of 78 patients with blood culture-negative infections shows CT-guided biopsy plus metagenomic sequencing achieves high pathogen detection (91%), but lacks a prospective design, concurrent control arm, and hard clinical outcome data to establish practice-changing impact.
Reported
Sample size78
Metagenomic next-generation seque…91.0% (71/78)
Conventional culture detection ra…55.1% (43/78)