Journal of Human Immunity

OCT 23, 2026 · JOURNAL ARTICLE

NFKB1 truncation-associated recurrent, sterile inflammation effectively treated with IL-1β blockade.

Journal of Human Immunity

Recurrent, sterile inflammatory responses to surgery and trauma in a patient with a heterozygous, truncating NFKB1 variant are described. This case illustrates the autoinflammatory

OCT 20, 2026 · JOURNAL ARTICLE

BCL10 deficiency: Long-term immune reconstitution following hematopoietic stem cell transplantation.

Journal of Human Immunity

BCL10 deficiency is a rare combined immunodeficiency characterized by severe infections, chronic diarrhea, hypogammaglobulinemia, and impaired lymphocyte activation despite preserv

OCT 20, 2026 · JOURNAL ARTICLE

The ups and downs of human UNC93B1: Autoimmune and viral conditions.

Journal of Human Immunity

Mouse Unc93b1 was identified in 2006 by forward genetics as an ER membrane protein essential for the activity of the endosomal nucleic acid-sensing receptors TLR3, TLR7, and TLR9.

JUL 14, 2026 · JOURNAL ARTICLE

Base Editing Hematopoietic Stem/Progenitor Cell Gene Therapy for Treatment of X-Linked Severe Combined Immunodeficiency

Journal of Human Immunity

First-in-human Phase I/II trial with only 3 patients treated and 6-month follow-up data reported for one patient; early data suggest safety and potential efficacy but remain insufficient for definitive clinical guidance.