Journal of Clinical Oncology

OCT 24, 2026 · JOURNAL ARTICLE

ENZARAD (ANZUP 1303): Phase 3 Trial of Enzalutamide With Androgen Deprivation Therapy and Radiation Therapy in High-Risk Localized or Locally Advanced Prostate Cancer

Journal of Clinical Oncology

Background The effects of adding enzalutamide to androgen deprivation therapy (ADT) and radiotherapy for high-risk localized or locally advanced prostate cancer were unknown. Metho

OCT 24, 2026 · JOURNAL ARTICLE

COMPANION-002: A Randomized Phase 2/3 Trial of Tovecimig Plus Paclitaxel versus Paclitaxel Alone as a Second-line Therapy in Patients with Advanced Biliary Tract Cancer

Journal of Clinical Oncology

Purpose Patients with previously treated biliary tract cancer (BTC) have a short median overall survival (OS), and few treatment options. Tovecimig, a bispecific antibody to delta-

OCT 14, 2026 · JOURNAL ARTICLE

Treatment of Advanced Biliary Tract Cancer: ASCO Living Guideline, Version 2026.1.0

Journal of Clinical Oncology

PURPOSE This living guideline provides recommendations for liquid biopsy and treatment of patients with advanced biliary tract cancer. METHODS The American Society of Clinical Onco

OCT 14, 2026 · JOURNAL ARTICLE

Dose-Escalated Focal Salvage High-Dose-Rate Brachytherapy and Genomic Classifier Risk Stratification in Radiorecurrent Prostate Cancer: The F-SHARP Phase I/II Clinical Trial

Journal of Clinical Oncology

Purpose Prospective data on the management of intraprostatic radiorecurrence (IPR) after definitive radiotherapy (RT) and use of genomic classifiers (GC) in this setting are limite

OCT 14, 2026 · JOURNAL ARTICLE

Neurodevelopmental Blueprint in Gliomas: Toward an Ontogenetic Multimodal Integrated Therapy

Journal of Clinical Oncology

Neuroepithelial tumors, including diffuse gliomas and embryonal neoplasms, remain among the most lethal cancers despite major advances in molecular diagnostics and some novel targe

OCT 12, 2026 · JOURNAL ARTICLE

Randomized Trial of Hypofractionated Postmastectomy Radiation Therapy in Women With Breast Reconstruction (RT CHARM, Alliance A221505)

Journal of Clinical Oncology

PURPOSE Patients with breast cancer requiring postmastectomy radiation therapy (PMRT) often desire breast reconstruction. Reconstructions can be adversely affected by PMRT, and fea

OCT 7, 2026 · JOURNAL ARTICLE

NRG-BR002: A Randomized Phase II/III Trial of Metastasis-Directed Ablation With First-Line Systemic Therapy for Oligometastatic Breast Cancer

Journal of Clinical Oncology

PURPOSE Metastasis-directed therapy is increasingly used for oligometastatic breast cancer, despite its uncertain benefit during first-line systemic therapy. We evaluated whether m

SEP 21, 2026 · JOURNAL ARTICLE

Patient-Level Evaluation of Optimal Margin Width for Lumpectomy in Ductal Carcinoma In Situ: An Analysis of Patients in the National Cancer Database Special Study

Journal of Clinical Oncology

PURPOSE Re-excision for close margins in patients undergoing breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) aims to reduce recurrence rates. The current recomm