Journal of Cancer Research and Clinical Oncology

OCT 23, 2026 · JOURNAL ARTICLE

CAR-NK cell immunotherapy: a comprehensive review of engineering platforms, clinical applications in hematological and solid tumors

Journal of Cancer Research and Clinical Oncology

Abstract Chimeric antigen receptor–natural killer (CAR-NK) cells combine innate cytotoxicity with antigen-directed killing and promise as an immunotherapy with lower cytokine toxic

OCT 20, 2026 · JOURNAL ARTICLE

Combination of oral fluoropyrimidines and EGFR-directed antibodies in frail patients with metastatic colorectal cancer: a systematic review

Journal of Cancer Research and Clinical Oncology

Abstract Background Evidence of treatment strategies in frail patients (i.e. not fit for combination therapies) with unresectable metastatic colorectal cancer (mCRC) is limited to

OCT 15, 2026 · JOURNAL ARTICLE

Aqueous and flavonoid-rich Carica papaya leaf extracts modulate 7, 12-dimethylbenz[a]anthracene-induced breast carcinogenesis in rats: roles of oxidative stress, inflammation, and in silico docking

Journal of Cancer Research and Clinical Oncology

Abstract Purpose Carica papaya leaves (CPL), traditionally used in ethnomedicine to manage inflammatory conditions and as an adjuvant in therapies, have been reported to have antic

OCT 9, 2026 · JOURNAL ARTICLE

Bioinformatic landscapes of TTK-mediated ceRNA networks: new horizons for targeted therapy in lung adenocarcinoma

Journal of Cancer Research and Clinical Oncology

Abstract Objective This study identifies TTK as a prognostic LUAD biomarker regulated by a ceRNA network, driving immune evasion and therapeutic resistance. Methods An integrated i

SEP 25, 2026 · JOURNAL ARTICLE

Integrated single-cell and spatial transcriptomic analysis characterizes a TNBC-enriched EP5-associated malignant epithelial program and prioritizes REEP4 in breast cancer

Journal of Cancer Research and Clinical Oncology

Triple-negative breast cancer (TNBC) exhibits pronounced epithelial-state plasticity, aggressive clinical behavior, and heterogeneous responses to immune checkpoint blockade (ICB)-

SEP 18, 2026 · JOURNAL ARTICLE

KHYG-1 cells retain functionality following exposure to the tumour and omental microenvironments of patients with obesity-associated cancer

Journal of Cancer Research and Clinical Oncology

Natural killer (NK) cell dysfunction has been extensively reported in obesity and cancer. In the setting of obesity-associated cancers such as oesophagogastric adenocarcinomas (OAC

SEP 10, 2026 · JOURNAL ARTICLE

The CD73-adenosine axis in NSCLC: expression regulation, pro-tumor mechanisms, and combination therapy

Journal of Cancer Research and Clinical Oncology

A narrative review summarizing current evidence on CD73-adenosine biology and therapeutic strategies in NSCLC, without new primary data or meta-analysis.

AUG 11, 2026 · JOURNAL ARTICLE

Clinical and translational profiling of oncotherad (MRB-CFI-1) nanoimmunotherapy identifies HER-2/SERBP1–associated recurrence and HABP4/IFN-γ–associated disease control in pT1 non-muscle-invasive bladder cancer after BCG failure

Journal of Cancer Research and Clinical Oncology

Single-center retrospective cohort of 21 patients with identified biomarkers and clinical outcomes, but lacking prospective validation, control group, and adequate power to establish causality or guide practice.