International Journal of Molecular Sciences

OCT 23, 2026 · JOURNAL ARTICLE

Curcumin Sensitizes Colorectal Cancer Cells to TRAIL-Mediated Apoptosis

International Journal of Molecular Sciences

Colorectal cancer (CRC) remains a major clinical challenge due to resistance to conventional cell death-inducing therapies. TRAIL selectively induces apoptosis in cancer cells via

OCT 21, 2026 · JOURNAL ARTICLE

Vitamin D in Digestive Neoplasms: Molecular Mechanisms and Clinical Evidence

International Journal of Molecular Sciences

Digestive neoplasms represent a major global health burden, accounting for a substantial proportion of cancer incidence and mortality. Increasing attention has been directed toward

OCT 21, 2026 · JOURNAL ARTICLE

Beyond Homologous Recombination: Functional Modules of Olaparib Resistance Revealed by CRISPR Screens

International Journal of Molecular Sciences

Clinical use of PARP inhibitors (PARPi), including olaparib, has improved outcomes for patients with BRCA1/2-mutant and homologous recombination (HR)-deficient tumors. However, acq

OCT 20, 2026 · JOURNAL ARTICLE

Multimodal Evaluation of [225Ac]Ac-PSMA-617 Therapy in mCRPC: PET Based Total Tumor Volume, PSA Kinetics, and Blood Biomarkers

International Journal of Molecular Sciences

This retrospective analysis interrogates the value of a multimodal biomarker paradigm to characterize molecular and clinical responses to [225Ac]Ac-PSMA-617-targeted α-therapy (TAT

OCT 19, 2026 · JOURNAL ARTICLE

Safety and Antitumor Activity of the Usnic Acid Derivative OL9-116, a TDP1 Inhibitor, as an Adjunctive Therapy in Combination with Topotecan

International Journal of Molecular Sciences

Topotecan inhibits topoisomerase 1 (TOP1) by trapping the enzyme in a DNA-cleavage complex, which can be repaired by tyrosyl-DNA phosphodiesterase 1 (TDP1). The usnic acid derivati

OCT 19, 2026 · JOURNAL ARTICLE

Prognostic Value of lncRNA H19 in Gastric Cancer: A Systematic Review and Meta-Analysis

International Journal of Molecular Sciences

LncRNA H19 is a crucial regulatory player in GC and could operate as an attractive biomarker for patient prognosis. This meta-analysis aims to gauge the link between lncRNA H19 exp

OCT 16, 2026 · JOURNAL ARTICLE

The NLRP3 Inflammasome Across the AKI–AKD–CKD Continuum: Mitochondrial, Epigenetic and Endocrine–Metabolic Regulation

International Journal of Molecular Sciences

The NLRP3 inflammasome has emerged as a potential molecular link between cellular stress, sterile inflammation, and progressive kidney damage. This review critically examines canon

OCT 16, 2026 · JOURNAL ARTICLE

Exploring Pathophysiological Processes Shared Between Type 2 Diabetes Mellitus and Osteoarthritis

International Journal of Molecular Sciences

Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are highly prevalent chronic disorders with increasing global burdens that frequently coexist and share common risk factors,