International Journal of Molecular Sciences

SEP 8, 2026 · JOURNAL ARTICLE

Targeting Cancer Hallmarks with Cirsium japonicum: Molecular Mechanisms and Therapeutic Potential

International Journal of Molecular Sciences

A narrative review of mechanistic evidence from in vitro and preclinical studies, lacking clinical trials, efficacy data, or validated targets in humans; raises questions for investigation rather than answering them.

SEP 8, 2026 · JOURNAL ARTICLE

Intrapancreatic Fat and Risk of Pancreatic Ductal Adenocarcinoma—Pathophysiology, Clinical Implications, and Future Directions

International Journal of Molecular Sciences

This is a narrative review summarizing existing evidence and proposing intrapancreatic fat as a biologically plausible mediator of pancreatic cancer risk, rather than presenting primary empirical evidence or a definitive causal relationship.

SEP 8, 2026 · JOURNAL ARTICLE

The Genomic Patterns of Well-Differentiated Pancreatic Neuroendocrine Tumors (NETs) Identify Sub-Sets for Rational Therapeutic Targeting

International Journal of Molecular Sciences

This is an exploratory genomic analysis of publicly available data identifying potential molecular subsets of pancreatic NETs, raising questions about prognostic stratification but lacking validation, clinical outcomes, or therapeutic testing.

SEP 5, 2026 · JOURNAL ARTICLE

Unlocking the Potency of Keyhole Limpet Hemocyanin: Structural Insights, Immunological Mechanisms, and Therapeutic Frontiers

International Journal of Molecular Sciences

This is a narrative review synthesizing existing knowledge on KLH structure and immunological mechanisms; it raises questions about therapeutic potential but does not present original clinical trial data or definitive evidence of efficacy.

SEP 4, 2026 · JOURNAL ARTICLE

Targeting Reactive Species Stress and Nutrient Sensing to Enhance NK-Cell Function: Mechanistic Strategies for Overcoming Pancreatic Cancer Progression and Resistance Through Supplement Therapy

International Journal of Molecular Sciences

A narrative review proposing mechanistic hypotheses about supplement-based NK cell enhancement in pancreatic cancer, without reporting primary experimental data or clinical trial results.

SEP 3, 2026 · JOURNAL ARTICLE

Myeloid-Derived Suppressor Cells (MDSCs) in Cardiovascular Risk of Obesity-Associated Diabetes

International Journal of Molecular Sciences

This is a narrative review synthesizing preclinical mechanisms and observational human data on MDSC biology in cardiometabolic disease, raising questions about dualistic roles rather than reporting new empirical results.

AUG 18, 2026 · JOURNAL ARTICLE

Comparative Transcriptomic Analysis of Oral Squamous Cell Carcinoma with Progressive Cisplatin Resistance

International Journal of Molecular Sciences

In vitro mechanistic study using cell line models to explore transcriptional changes associated with cisplatin resistance; raises questions about EMT involvement rather than answering clinical questions with human data.

AUG 18, 2026 · JOURNAL ARTICLE

BOLD-100 in Combination with FOLFOX Is a Broadly Effective Therapeutic Strategy for Gastric Cancer

International Journal of Molecular Sciences

Preclinical organoid study testing drug combinations in vitro; no clinical outcomes, patient data, or in vivo validation reported.