JUL 14, 2026 · JOURNAL ARTICLE
Gain- and loss-of-function of Engrailed 1 in mesenchymal stromal cells affect their potential to differentiate into osteoblasts and to repair bone tissue
International Journal of Biological Macromolecules
Sound preclinical study with gain- and loss-of-function design and in vivo validation in a bone defect model, but limited to animal model and lacks human clinical endpoints or translation.
Study details
DesignPreclinical mechanistic study with CRISPR-b…
InterventionCRISPR-Cas9-based En1 overexpression in MSC…
ComparatorEn1-silenced (loss-of-function) MSCs and im…