International Immunopharmacology

OCT 23, 2026 · JOURNAL ARTICLE

Targeted inhibition of HK2 expression in pancreatic ductal adenocarcinoma reprogrammes the immune microenvironment by regulating CCL5-mediated CD8+ T cell infiltration

International Immunopharmacology

Background Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to immune checkpoint inhibitor (ICI) therapy due to its highly immunosuppressive tumor microenvironment (TME)

SEP 13, 2026 · JOURNAL ARTICLE

Inflammation biomarkers in cancer: mechanistic drivers, diagnostic innovations, and future clinical horizons

International Immunopharmacology

Chronic inflammation is a universally acknowledged characteristic of cancer, playing the role of a vital catalyst in cancer initiation and progression, and a chief predictor of the

SEP 13, 2026 · JOURNAL ARTICLE

Multi-omics and spatial transcriptomics reveal that S100A10 drives CD8+ T-cell exhaustion and immune evasion in hepatocellular carcinoma through cPLA2-5-LOX-mediated arachidonic acid metabolism and ferroptosis

International Immunopharmacology

Immune evasion in hepatocellular carcinoma (HCC) represents a major biological barrier limiting the efficacy of immunotherapy, yet its molecular basis remains incompletely understo

SEP 12, 2026 · JOURNAL ARTICLE

Macrophage HDAC3 drives obesity and adipose tissue metabolic maladaptation through GDF3-mediated inflammation and chromatin remodeling

International Immunopharmacology

Chronic inflammation is a hallmark of obesity and its associated metabolic disorders. Adipose tissue macrophages (ATMs) play a crucial role in maintaining tissue homeostasis and or

AUG 15, 2026 · JOURNAL ARTICLE

Pre-treatment T cell phospho-signalling identifies clinical pembrolizumab response in non-small cell lung cancer patients

International Immunopharmacology

A single-centre, exploratory biomarker study with moderate sample size showing an association between ex vivo T cell phospho-signalling and overall survival (HR 2.83, p=0.013), but requiring validation in independent cohorts before clinical application.