SEP 12, 2026 · JOURNAL ARTICLE
Single-Cell Transcriptomics Uncovers β-Elemene-Induced Macrophage Reprogramming as a Mechanism to Suppress Osteosarcoma Stemness via the CCL2-Akt Axis
Immunological Investigations
Background β-elemene (ELE), a natural sesquiterpene with antitumor properties, exerts immunomodulatory effects on osteosarcoma (OS), but its impact on the tumor microenvironment an