AUG 24, 2026 · JOURNAL ARTICLE
Clinical validation of KIF11 overexpression in colorectal cancer and its potential association with the antitumor effects of nitidine chloride
Hereditas
This is a mechanistic discovery study combining computational prediction, molecular profiling, and cell-based experiments that propose KIF11 as a target and NC as a candidate agent, but lacks clinical efficacy data, adequate in vivo validation, or direct evidence of NC's antitumor effect in animal models.
Reported
Molecular docking binding energy−9.0 kcal/mol
Meta-analysis standardized mean d…1.33
Meta-analysis AUC for KIF11 mRNA0.87