Gut Microbes

AUG 27, 2026 · JOURNAL ARTICLE

Microbiome-based therapeutics for Clostridioides difficile infection: additive, subtractive, and modulatory strategies in modern clinical practice

Gut Microbes

A narrative review synthesizing current evidence and conceptual frameworks for microbiome-based CDI therapeutics, intended to guide clinical practice and future research design rather than report new empirical findings.

AUG 25, 2026 · JOURNAL ARTICLE

Gut microbial diversity at baseline conditions the clinical, microbiome, and metabolic response to paraprobiotic Lactiplantibacillus plantarum LRCC5282 in overweight adults.

Gut Microbes

A well-designed RCT showing no overall effect, but a pre-specified subgroup analysis (low baseline microbial diversity) demonstrated significant clinical improvements with mechanistic support from microbiome and metabolite data; requires confirmation in a prospective, diversity-stratified trial.

AUG 24, 2026 · JOURNAL ARTICLE

Baseline gut microbiome ecology predicts long-term fat mass loss after bariatric surgery: evidence for a thrifty Bifidobacterium phenotype.

Gut Microbes

A prospective observational study with a clear finding linking baseline microbiome composition to long-term fat mass loss after bariatric surgery, but limited by single-centre design, lack of randomization, and modest sample size.

AUG 23, 2026 · JOURNAL ARTICLE

Natural microbiota confer life-long protection against obesity via an early-life, immune-mediated effect on brown adipocytes.

Gut Microbes

A mechanistic murine study with multi-faceted evidence (RNA sequencing, genetic knockouts, adoptive transfer) identifying a microbiota–immune pathway to obesity resistance, but limited by preclinical design and absence of human validation.

AUG 21, 2026 · JOURNAL ARTICLE

From gut to brain: data-driven evidence suggests causal contribution of gut-microbiota to major depressive disorder in humans.

Gut Microbes

A large, well-characterized observational cohort with rigorous causal inference methods identifies specific taxa associated with MDD, but causal claims rest on computational inference from cross-sectional data rather than experimental validation.

AUG 18, 2026 · JOURNAL ARTICLE

Amino acid metabolic reprogramming by gut microbiota: a novel metabolic checkpoint in the tumor microenvironment

Gut Microbes

This is a narrative review synthesizing preclinical and clinical evidence on mechanistic relationships between gut microbiota, amino acid metabolism, and cancer, raising questions rather than answering them with primary data.

AUG 15, 2026 · JOURNAL ARTICLE

Synthetic microbial communities: emerging live biotherapeutics for targeted gut microbiome modulation.

Gut Microbes

A narrative review synthesizing the state of knowledge on synthetic microbial communities as emerging biotherapeutics, establishing boundaries, mechanisms, and translational challenges without reporting primary experimental results.

AUG 4, 2026 · JOURNAL ARTICLE

Early-life microbiota in the LIMIT cohort: unveiling meconium microbiota types beyond maternal lifestyle.

Gut Microbes

Observational cohort study identifying novel meconium microbiota clusters with no significant associations to maternal lifestyle factors; findings are exploratory and require longitudinal validation.