Genome Medicine

OCT 24, 2026 · JOURNAL ARTICLE

Spatial transcriptomics landscape of livers from patients with metabolic dysfunction-associated steatohepatitis

Genome Medicine

Metabolic dysfunction-associated steatohepatitis (MASH) progression involves heterogeneous responses and coordinated interactions among parenchymal and nonparenchymal cells. Single

SEP 30, 2026 · JOURNAL ARTICLE

DrugSAGE: a transcriptome aggregation approach using cell lines for drug response imputation

Genome Medicine

Accurate drug response prediction is essential for optimizing cancer therapy, yet genomic heterogeneity drives variable responses even among tumors with identical driver mutations.

SEP 25, 2026 · JOURNAL ARTICLE

Cross-population genome-wide meta-analysis identifies pancreatic cancer susceptibility loci and etiologic pathways

Genome Medicine

Abstract Background Pancreatic cancer is a fatal malignancy influenced by genetic, metabolic, and lifestyle factors. We aimed to identify susceptibility loci and clarify associated

SEP 18, 2026 · JOURNAL ARTICLE

Longitudinal mapping of the blood proteome to blood metabolome reveals the role of the protein-metabolite axes in metabolic health

Genome Medicine

The proteomic determinants of blood metabolites have rarely been systematically investigated in population-based studies. Identifying protein-metabolite pairs could help elucidate

SEP 16, 2026 · JOURNAL ARTICLE

Uncovering pan-cancer signatures of chemoresistance

Genome Medicine

Abstract Background Chemotherapy resistance remains a formidable challenge in cancer treatment, driving high mortality rates worldwide. Despite significant advancements, it remains

JUL 31, 2026 · JOURNAL ARTICLE

Phenotype rescue through the restoration of full-length dystrophin using CRISPR/Cas9 genome editing in Duchenne muscular dystrophy patient-derived iPSCs carrying the deletion of two exons

Genome Medicine

First-in-human demonstration of CRISPR/Cas9 correction of multi-exon DMD deletion in patient iPSCs with rescue of in vitro cardiac phenotypes, but limited to a single cell line, surrogate endpoints, and no animal or clinical translation yet.