Genes

OCT 22, 2026 · JOURNAL ARTICLE

Beyond Mutation Positivity: Variant Allele Frequency as a Quantitative Biomarker in Precision Oncology

Genes

Next-generation sequencing has transformed precision oncology, yet genomic alterations are still largely interpreted as binary events: present or absent, actionable or non-actionab

OCT 19, 2026 · JOURNAL ARTICLE

Non-B DNA at the Interface of Metabolism, Genome Stability, and Inflammation

Genes

DNA most commonly adopts the canonical B-form double helix but can also form alternative conformations, collectively known as non-B DNA structures. These structures, including G-qu

SEP 28, 2026 · JOURNAL ARTICLE

Human Subcutaneous Adipose Transcriptomes Link Mitochondrial Transcription to Metabolic Heterogeneity in Obesity

Genes

Background: Metabolically healthy obesity and metabolically unhealthy obesity may occupy different positions along a continuum of adipose-tissue dysfunction, but stable molecular d

SEP 24, 2026 · JOURNAL ARTICLE

Ubiquitin Proteasome System BTB-Adaptor Protein Insomniac Modifies Seizure Severity and Response to the Ketogenic Diet in a Drosophila Model of Mitochondrial Encephalomyopathy

Genes

Background/Objectives: The ubiquitin proteasome system (UPS) serves critical cellular homeostatic functions that contribute to neurological health, including neuronal metabolism, s

SEP 19, 2026 · JOURNAL ARTICLE

Decoding MAPT Exon 10 Mis-Splicing in FTDP-17: From Pathogenic Mechanisms and Experimental Models to Molecular Therapies

Genes

Frontotemporal Dementia and Parkinsonism linked to chromosome 17 (FTDP-17) is a rare, early-onset, autosomal-dominant neurodegenerative tauopathy caused by mutations in the Microtu

SEP 17, 2026 · JOURNAL ARTICLE

Epigenomic Remodeling by Lipid Metabolism: A Cross-Disease Perspective on Cancer and Brain Disorders

Genes

Lipid metabolism is no longer viewed simply as a source of membrane biomass or ATP. It is now proposed as a regulatory system that determines which metabolites reach the nucleus, w

SEP 16, 2026 · JOURNAL ARTICLE

The Epigenetic Aging–Cancer Continuum: Biomarkers, Metabolism, and Therapy

Genes

Aging and cancer form a biological continuum influenced by epigenomic changes, metabolic dysfunction, inflammation, cellular senescence, and loss of tissue homeostasis. Age-related

SEP 7, 2026 · JOURNAL ARTICLE

Precision Oncology in Non-Small Cell Lung Cancer: Integrating Molecular Diagnostics, Targeted Therapies, and Resistance Mechanisms

Genes

A structured narrative review synthesizing evidence from 99 foundational studies and clinical documents to provide organized guidance on molecular biomarkers, diagnostic methods, and resistance mechanisms in NSCLC precision oncology, rather than reporting original trial data.