Frontiers in Pain Research

OCT 30, 2026 · JOURNAL ARTICLE

Mitochondrial-derived peptides: emerging therapeutic targets at the intersection of mitochondrial dysfunction and pain

Frontiers in Pain Research

Mitochondrial-derived peptides (MDPs), including humanin and MOTS-c, are endogenous peptide signaling molecules that regulate cellular stress responses and metabolic homeostasis. M

SEP 24, 2026 · JOURNAL ARTICLE

Metabolic and neuropathic outcomes following combined sodium-glucose cotransporter-2 inhibitor therapy and adjunctive acupuncture in obese patients with diabetic neuropathy: a case series

Frontiers in Pain Research

Background Obesity and type 2 diabetes mellitus (T2DM) are associated with chronic metabolic dysregulation and microvascular complications, including diabetic peripheral neuropathy

AUG 17, 2026 · JOURNAL ARTICLE

Impact of genetic polymorphisms on the response to transdermal fentanyl in cancer patients—a single-center, prospective, biological study

Frontiers in Pain Research

Single-center exploratory cohort with negative primary findings after multiple-testing correction; provides hypothesis-generating signals but insufficient evidence to guide clinical pharmacogenetic testing for fentanyl.