A hypothesis-generating, cross-sectional clustering study that identifies novel sub-phenotypes but lacks prospective validation, hard clinical outcomes, or causal evidence to guide clinical practice.
A narrative review synthesizing adverse event profiles across 14 NCCN-recommended systemic therapies for cutaneous T-cell lymphoma, designed to inform clinical treatment selection and monitoring rather than report new efficacy data.
This is a protocol paper for an ongoing Phase II trial with no results reported; it describes planned methodology and endpoints only, representing preliminary evidence generation in progress.
A narrative critical review synthesizing evidence across multiple indications, regulatory positions, and methodological quality of ozone therapy—informative for clinicians navigating heterogeneous evidence but not itself a primary research result.
A single fatal case report documenting an unusual dual infection in CGD with a novel genetic mutation; raises clinical awareness but provides no comparative data or interventional evidence.
This is an expert opinion piece articulating a conceptual framework for the evolution of theranostics from target discovery to integrated precision medicine, based on established evidence and clinical practice.
A perspective piece articulating international guideline recommendations (2025 ACC Statement, 2026 ACC/AHA guideline) and proposing an implementation framework for residual cardiovascular risk assessment in the Chinese population, without new primary trial data.
Single-centre retrospective observational study of modest size without comparator, describing testing and prescribing practices; generates actionable findings about stewardship but lacks the design or sample size to confirm causation or quantify intervention benefit.