Frontiers in Immunology

SEP 8, 2026 · JOURNAL ARTICLE

Targeted protein degradation dismantles undruggable targets to reverse immune evasion and therapy resistance in cancer

Frontiers in Immunology

A comprehensive review summarizing molecular principles, clinical progress, and translational strategies for targeted protein degradation in cancer immunotherapy, rather than reporting original experimental data or trial results.

SEP 8, 2026 · JOURNAL ARTICLE

Obesity and COVID-19 severity independently shape adipokine dysregulation and immune cell remodeling

Frontiers in Immunology

A well-designed cross-sectional study dissecting independent and interactive effects of obesity and COVID-19 severity on immune mediators and cell populations, with rigorous statistical approach, but limited by lack of longitudinal follow-up, hard clinical outcomes, or external validation of biomarker utility.

SEP 8, 2026 · JOURNAL ARTICLE

Case Report: Invasive mucinous adenocarcinoma mimicking interstitial pneumonia with autoimmune features: diagnostic pitfalls and reflections

Frontiers in Immunology

A single case report describing diagnostic misidentification of lung cancer as autoimmune interstitial pneumonia; raises awareness of a pitfall but provides no comparative data or outcome measures to support clinical decision-making.

SEP 8, 2026 · JOURNAL ARTICLE

Carnosic acid alleviates 5-Fluorouracil chemoresistance and enhances CD8+ T cell cytotoxicity in gastric cancer by regulating the CXCL12/CXCR7 axis

Frontiers in Immunology

Preclinical study using cell lines and mouse models with mechanistic findings; no human trials, no clinical efficacy data, and no quantified effect sizes reported.

SEP 8, 2026 · JOURNAL ARTICLE

An endoplasmic reticulum stress- and Golgi apparatus-related signature reveals immune microenvironment remodeling and MUC16-driven PI3K/AKT activation in lung adenocarcinoma

Frontiers in Immunology

A machine learning signature study with in vitro validation of a candidate gene, but lacking prospective clinical validation, hard clinical endpoints, or therapeutic trial data to support clinical implementation.

SEP 8, 2026 · JOURNAL ARTICLE

Transmembrane lectins in cancer immunity: emerging drivers of myeloid-mediated immunosuppression

Frontiers in Immunology

A narrative review synthesizing mechanistic concepts and therapeutic potential of lectin–glycan interactions in cancer immunity, raising questions rather than reporting empirical results or clinical outcomes.

SEP 8, 2026 · JOURNAL ARTICLE

Deciphering defensive mechanisms in Riemerella anatipestifer infection: pathogen adaptation, host immune response and emerging strategies

Frontiers in Immunology

This is a narrative review synthesizing fragmented mechanistic and immunological evidence on a pathogen; it raises questions about host-pathogen dynamics rather than reporting original empirical results or definitive answers.

SEP 8, 2026 · JOURNAL ARTICLE

Tertiary lymphoid structures in urothelial carcinoma: bridging spatial architecture with therapeutic vulnerability in the post-BCG era

Frontiers in Immunology

A narrative review synthesizing current evidence and raising mechanistic questions about tertiary lymphoid structures in urothelial carcinoma, without new empirical data or prospective validation of proposed biomarker relationships.