Frontiers in Endocrinology

OCT 23, 2026 · JOURNAL ARTICLE

Hepatobiliary adverse-event reporting patterns for endocrine therapies in breast cancer: a pharmacovigilance study based on FAERS and VigiAccess

Frontiers in Endocrinology

Background Endocrine therapy is central to the treatment of hormone receptor-positive breast cancer, yet hepatobiliary adverse-event reporting across endocrine agents remains incom

OCT 23, 2026 · JOURNAL ARTICLE

Tissue-resolved transcriptomic and proteomic profiling reveals organ-specific molecular signatures associated with inter-animal variation in glycemic response to metformin in obese diabetic Mongolian gerbils

Frontiers in Endocrinology

Background Type 2 diabetes mellitus (T2DM) affects hundreds of millions of people worldwide. Metformin remains first-line therapy for obese T2DM; yet, 30–40% of patients fail to ac

OCT 23, 2026 · JOURNAL ARTICLE

Will GLP-1-based therapies reshape the epidemiology of MASLD? An emerging public health perspective

Frontiers in Endocrinology

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease worldwide, driven by increasing obesity and type 2 diabetes mellitus.

OCT 22, 2026 · JOURNAL ARTICLE

Dysfunction and therapeutic potential of brown adipose tissue and batokines in obesity and type 2 diabetes mellitus

Frontiers in Endocrinology

Obesity and Type 2 Diabetes Mellitus (T2D) remain key drivers of premature mortality, morbidity, and healthcare expenditure globally. Although we have witnessed dramatic recent adv

OCT 22, 2026 · JOURNAL ARTICLE

Thyroid dysfunction in aging and cardiovascular-kidney-metabolic syndrome: metabolic regulation and clinical implications

Frontiers in Endocrinology

Thyroid hormones are involved in multiple metabolic pathways in the body and are essential for maintaining organ functions across the lifespan. Aging-related thyroid dysfunction ha

OCT 22, 2026 · JOURNAL ARTICLE

Bidirectional relationship between diabetes and pancreatic cancer: from mechanistic investigation to clinical application

Frontiers in Endocrinology

A well-established bidirectional causal relationship connects type 2 diabetes mellitus (T2DM) and pancreatic ductal adenocarcinoma (PDAC). Long-standing T2DM elevates pancreatic ca

OCT 22, 2026 · JOURNAL ARTICLE

Mechanism-based therapeutic strategies in cardiovascular-kidney-metabolic syndrome: integrating biological pathways with evidence from clinical trials

Frontiers in Endocrinology

Cardiovascular-kidney-metabolic (CKM) syndrome describes the close relationship between metabolic dysfunction, chronic kidney disease, and cardiovascular disease, which share sever

OCT 21, 2026 · JOURNAL ARTICLE

Associations of fasting blood glucose and the triglyceride–glucose index with aggressive pathological features of papillary thyroid carcinoma

Frontiers in Endocrinology

Background The prevalence of papillary thyroid carcinoma (PTC) along with abnormal glucose-lipid metabolism and obesity is rising. Metabolic abnormalities may be associated with ad