AUG 8, 2026 · REVIEW
Impact of glucagon-like peptide-1 receptor agonists on outcomes following anterior cervical discectomy and fusion: a systematic review and meta-analysis
European Spine Journal
Systematic review of 8 retrospective cohort studies (311,402 patients) demonstrates consistent, significant reduction in pseudarthrosis odds with GLP-1RA use at 6, 12, and 24 months, but evidence for other complications remains heterogeneous and inconclusive, limiting practice-changing strength.
Reported
Total sample size311402
GLP-1RA users (matched to non-use…8182
Pseudarthrosis odds ratio at 6 mo…0.60