Background Major psychiatric illnesses are highly heritable, yet the search for replicable genetic and neurobiological mechanisms has proven highly challenging. One of the major re
Background Large-scale genome-wide association studies (GWASs) have accelerated genomic discovery for major depressive disorder (MDD), but important limitations persist. To date, m
While recent genome-wide association studies (GWAS) have shown that antidepressant response has a genetic component, the robust identification of genetic associations in current st
Background Bipolar disorder (BIP) is a highly heritable and severe mental disorder characterized by depressive and manic (Type I) or hypomanic episodes (Type II). While GWAS of BIP
Given the heritability of mental disorders it is not surprising that prevalence rates for mental disorders are increased in children of parents with mental illness as well as in pa