Background: Weight loss improves obesity-associated metabolic dysfunction, yet resolution of adipose inflammation may be incomplete and can reappear during weight regain. Whether h
Cross-sectional study with adequate sample size demonstrating independent association between insulin resistance and trabecular bone quality (not density) in obesity; mechanistic insight but no intervention or longitudinal outcome data.
Retrospective cohort study with clear methodology and pre-specified outcome showing sarcopenic obesity as an independent predictor of new-onset diabetes after pancreaticoduodenectomy, but limited by single-centre design, non-randomized conduct, and modest sample size for the 1-year analysis.