Drug Development Research

OCT 22, 2026 · JOURNAL ARTICLE

Advancements of Emerging Thiazole‐Based CDKs Inhibitors for Cancer Therapy: From Hits to Clinical Candidates

Drug Development Research

ABSTRACT Cyclin‐dependent kinases (CDKs) represent highly attractive anticancer targets and several inhibitors have been approved for cancer therapy. However, drug resistance and d

AUG 17, 2026 · JOURNAL ARTICLE

Dioscin Reverses Drug Resistance via AKT/GSK3β‐mediated P‐gp Degradation and EMT Inhibition

Drug Development Research

Mechanistic study in resistant cell lines with in vivo xenograft validation, but no clinical trial data, no comparative chemotherapy arm, and no human efficacy or safety evidence.