To identify circulating microRNA (miRNA) signatures associated with metabolic health status independent of body mass index (BMI) and to characterize their underlying regulatory pat
Metabolically unhealthy obesity (MUO) is characterized by adipose tissue dysfunction and insulin resistance (IR), though the causal genetic drivers remain elusive. We applied multi
Excess adiposity is increasingly prevalent worldwide and is associated with substantial cardiovascular-kidney–metabolic (CKM) morbidity. This study aimed to quantify the prevalence
Prospective cohort study with 19.6-year median follow-up, hard clinical endpoint (incident ASCVD), and consistent dose–response relationships across multiple abdominal obesity measures with statistical significance and robust sensitivity analyses.
A rigorous systematic review and meta-analysis of 16 RCTs confirms that microbiota-targeted interventions do not substantially improve metabolic syndrome parameters in adolescents with obesity, reinforcing the current evidence of limited efficacy.
A systematic umbrella review of 72 meta-analyses synthesizing evidence from 7,367 articles on 101 risk factors for metabolic syndrome, providing comprehensive pooled estimates with confidence intervals and heterogeneity assessment.
Meta-analysis of six observational cohort studies showing a statistically significant 26% lower hazard of AF recurrence with GLP-1RA therapy, but low certainty of evidence and lack of randomized data limit strength.
Systematic comparison of three rat models against clinical PMOS features, but uncontrolled animal work with small per-group samples (n=8) and no between-model statistical testing reported; provides descriptive phenotypic characterization to guide model selection rather than a testable clinical or mechanistic finding.