A systematic umbrella review of 72 meta-analyses synthesizing evidence from 7,367 articles on 101 risk factors for metabolic syndrome, providing comprehensive pooled estimates with confidence intervals and heterogeneity assessment.
Meta-analysis of six observational cohort studies showing a statistically significant 26% lower hazard of AF recurrence with GLP-1RA therapy, but low certainty of evidence and lack of randomized data limit strength.
Systematic comparison of three rat models against clinical PMOS features, but uncontrolled animal work with small per-group samples (n=8) and no between-model statistical testing reported; provides descriptive phenotypic characterization to guide model selection rather than a testable clinical or mechanistic finding.