Large prospective cohort study with rigorous metabolic health definition and hard clinical endpoint (incident diabetes), demonstrating clear dose-response relationships and population-specific BMI thresholds in East Asian adults.
A narrative review synthesizing existing clinical evidence and mechanistic pathways to reappraise fibrate therapy within a proposed disease framework, intended to inform clinical thinking rather than report new trial results.
A narrative review synthesizing current evidence on hypercortisolism in Type 2 diabetes, recommending targeted case-finding strategy and DST screening approach rather than universal screening.
Protocol optimization study in animal models comparing five inbred mouse regimens; provides useful characterization for researchers but lacks clinical outcomes, human translation, or definitive evidence for therapeutic testing.
Mechanistic proof-of-concept study in cell culture and rodent models identifying a pathway but lacking human efficacy or safety data needed to guide clinical practice.