Diabetes

SEP 3, 2026 · JOURNAL ARTICLE

Sex- and Ketogenesis-Dependent Effects of Intermittent Fasting on Diet-Induced Fatty Liver Disease

Diabetes

Mechanistic animal study identifying sex-dependent pathways in intermittent fasting; raises questions about human applicability and sex-specific therapeutic design rather than establishing clinical evidence.

AUG 18, 2026 · JOURNAL ARTICLE

Organelle-Specific Lipid Profiles Underlie Metabolic Health in a Nutrition-Dependent Manner

Diabetes

Mechanistic study in mice using organelle lipidomics to explore how Western diet remodels subcellular lipid pools; identifies associations between lipid signatures and metabolic phenotype but lacks human validation or intervention testing.

AUG 17, 2026 · JOURNAL ARTICLE

Body Composition–Driven Phenotyping Reveals Obesity and Cardiometabolic Heterogeneity in Children Using a Tree-Like Representation

Diabetes

A well-designed, large single-cohort discovery study with independent validation that identifies clinically relevant body composition phenotypes and their cardiometabolic risk associations, but uses surrogate endpoints and spatial clustering metrics rather than hard clinical outcomes.

AUG 11, 2026 · JOURNAL ARTICLE

Substrate-Selective Lipolysis Facilitates Unsaturated TAG Accumulation in Obesity

Diabetes

Mechanistic study in adipocytes proposing a novel enzymatic substrate selectivity mechanism; lacks clinical outcomes, hard endpoints, or in vivo validation of the proposed pathway.