Diabetes

OCT 19, 2026 · JOURNAL ARTICLE

Amino Acid Profiles Distinguish Glycemic Phenotypes in Childhood and Predict 10-Year Risk of Dysglycemia in Young Adults: The BCAMS Study

Diabetes

Amino acid (AA) dysregulation has been associated with metabolic diseases. However, its potential as a childhood determinant of adult diabetes risk remains understudied, particular

OCT 14, 2026 · JOURNAL ARTICLE

Skeletal Muscle DPT Ameliorates Obesity and Metabolic Dysfunction via the PERK/eIF2α/ATF4-GDF15 Axis

Diabetes

Skeletal muscle plays a pivotal role in maintaining metabolic homeostasis by acting as a primary site for glucose disposal and insulin-mediated energy use. Here, through RNA sequen

SEP 18, 2026 · JOURNAL ARTICLE

Reduction in T-Cell Mitochondrial Respiratory Capacity After Reaching a Weight Loss Plateau

Diabetes

Experiencing an involuntary weight loss plateau is common after behavioral weight loss. During such periods, sustained negative energy balance activates counterregulatory mechanism

SEP 15, 2026 · JOURNAL ARTICLE

Phosphodiesterase 4 Inhibition Attenuates Diet-Induced Obesity and Activates BAT Thermogenic Pathways Through Central Mechanisms

Diabetes

Obesity is marked by chronic low-grade inflammation and impaired thermogenic function of brown adipose tissue (BAT), contributing to decreased energy expenditure. BAT dissipates en

SEP 3, 2026 · JOURNAL ARTICLE

Sex- and Ketogenesis-Dependent Effects of Intermittent Fasting on Diet-Induced Fatty Liver Disease

Diabetes

Mechanistic animal study identifying sex-dependent pathways in intermittent fasting; raises questions about human applicability and sex-specific therapeutic design rather than establishing clinical evidence.

AUG 18, 2026 · JOURNAL ARTICLE

Organelle-Specific Lipid Profiles Underlie Metabolic Health in a Nutrition-Dependent Manner

Diabetes

Mechanistic study in mice using organelle lipidomics to explore how Western diet remodels subcellular lipid pools; identifies associations between lipid signatures and metabolic phenotype but lacks human validation or intervention testing.

AUG 17, 2026 · JOURNAL ARTICLE

Body Composition–Driven Phenotyping Reveals Obesity and Cardiometabolic Heterogeneity in Children Using a Tree-Like Representation

Diabetes

A well-designed, large single-cohort discovery study with independent validation that identifies clinically relevant body composition phenotypes and their cardiometabolic risk associations, but uses surrogate endpoints and spatial clustering metrics rather than hard clinical outcomes.

AUG 11, 2026 · JOURNAL ARTICLE

Substrate-Selective Lipolysis Facilitates Unsaturated TAG Accumulation in Obesity

Diabetes

Mechanistic study in adipocytes proposing a novel enzymatic substrate selectivity mechanism; lacks clinical outcomes, hard endpoints, or in vivo validation of the proposed pathway.