Cureus

OCT 22, 2026 · JOURNAL ARTICLE

Proteogenomic Signatures in Complex Diseases: Implications for Targeted Interventions

Cureus

Complex diseases arise from interactions among genetic susceptibility, epigenetic regulation, transcriptomic variation, protein expression, environmental exposure, and clinical phe

OCT 20, 2026 · JOURNAL ARTICLE

Prevalence of Prehypertension and Its Association With Sedentary Lifestyle Indicators Among Adults: A Cross-Sectional Study

Cureus

BackgroundPrehypertension is a clinically important condition that precedes hypertension and substantially increases the risk of cardiovascular disease.Sedentary lifestyle behaviou

OCT 20, 2026 · JOURNAL ARTICLE

Efficacy and Safety of Once-Weekly Subcutaneous Semaglutide in Adolescents With Obesity: A Retrospective Study

Cureus

BackgroundChildhood and adolescent obesity are increasing public health concerns in India and are associated with cardiometabolic complications.However, real-world evidence on the

OCT 20, 2026 · JOURNAL ARTICLE

Exceptional Metabolic Response to Ribociclib and Letrozole in a Young Patient With De Novo Multimetastatic Luminal A Pleomorphic Lobular Breast Cancer: A Case Report

Cureus

Metastatic breast cancer (MBC) with a luminal A profile typically follows an indolent clinical course.However, the pleomorphic lobular subtype can manifest aggressive biology with

OCT 17, 2026 · JOURNAL ARTICLE

Global Convergence and Divergence in Clinical Practice Guidelines for Heart Failure With Preserved Ejection Fraction: A Systematic Comparative Review

Cureus

Heart failure with preserved ejection fraction (HFpEF) is a growing global health challenge, yet international clinical guidance remains heterogeneous.This review synthesizes HFpEF

OCT 16, 2026 · JOURNAL ARTICLE

Exploratory Study on the Association Between Pre-treatment Factors and Hematological Toxicity in Colorectal Cancer Patients Receiving CapeOX (Capecitabine Plus Oxaliplatin) Therapy

Cureus

Background: The capecitabine plus oxaliplatin (CapeOX) regimen is commonly used for adjuvant treatment and selected first-line treatment settings in colorectal cancer.However, hema

OCT 15, 2026 · JOURNAL ARTICLE

Individualized and Platform-Designated Gene-Editing Studies in the Registered Clinical Record: A Case-by-Case Census Against 148 Eligible Studies

Cureus

IntroductionIn February 2025, a single infant with carbamoyl phosphate synthetase 1 deficiency received a customized base-editing therapy, and individualized gene editing has since

OCT 13, 2026 · JOURNAL ARTICLE

Amrubicin-Induced Radiation Recall Pneumonitis After Low-Dose Palliative Thoracic Radiotherapy: A Case Report

Cureus

A 70-year-old man with extensive-stage small-cell lung cancer received palliative thoracic radiotherapy to a total dose of 18 Gy in six fractions for central airway stenosis.Five m