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Cochrane Database of Systematic Reviews

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SEP 4, 2026 · JOURNAL ARTICLE

Long-term hormone therapy for perimenopausal and postmenopausal women

Cochrane Database of Systematic Reviews

High-quality systematic review of 24 RCTs (45,660 participants) with moderate certainty evidence on long-term hormone therapy effects across multiple clinical outcomes; primarily powered by two well-conducted large trials (HERS, WHI) with low risk of bias.

Strong EvidenceLi Ning Yong Cindy Farquhar Christine Bekos

Reported

Sample size45660

Combined HT – Coronary events (RR)1.17

Combined HT – Coronary events (95…0.95 to 1.44

AUG 18, 2026 · JOURNAL ARTICLE

Metabolic and bariatric surgery in adults with obesity and diabetes mellitus: a network meta-analysis

Cochrane Database of Systematic Reviews

A rigorous network meta-analysis of 18 studies (13 RCTs, 5 cohort studies) with 15,282 participants using GRADE certainty assessment, showing consistent but imprecise evidence that RYGB, OAGB, and SG improve weight loss, waist circumference, and glycaemic control versus lifestyle/medical treatment in adults with obesity and type 2 diabetes.

Strong EvidenceLea Gorenflo Lukas Schwingshackl Guido Schwarzer

Reported

Sample size15282

RCTs included13

Cohort studies included5