Retrospective real-world registry analysis confirming sustained drug survival of guselkumab across weight, BMI, and comorbidity strata over 36 months, with consistent outcomes but limited by observational design and missing baseline data.
A well-designed cross-sectional study with adequate sample size and multivariable adjustment demonstrating clear differences in body composition between HS and comparators, but lacks longitudinal data or clinical outcome linkage to establish causation or clinical actionability.
A single case report documenting an observed phenomenon without experimental controls or comparison, providing descriptive evidence that warrants further investigation.