Chemmedchem

OCT 14, 2026 · JOURNAL ARTICLE

Inhibitors of PIM‐1 Signaling Pathways as Anticancer Agents: Pharmacological and Structural Viewpoints

Chemmedchem

Pim‐1, a carcinogenic threonine and serine kinase, inhibits apoptosis and advances the cell cycle. It is overexpressed in several human cancers. The proviral integration site of Mo

SEP 27, 2026 · JOURNAL ARTICLE

Assessment of the Binding Affinity of Covalent Inhibitors of Cruzain and Cathepsin L Using Relative Binding Free Energy

Chemmedchem

Cysteine proteases are recognized as relevant therapeutic targets in both parasitic diseases and cancer due to their essential biological functions. Among these enzymes, cruzain fr

SEP 5, 2026 · JOURNAL ARTICLE

Covalent Targeting and Thermostabilization of Oncogenic R280K and R273H Mutants p53 by Small Molecule RVJB59

Chemmedchem

In vitro mechanistic study of a small molecule binding to mutant p53 domains, with no cell-based or clinical data, raising a question about therapeutic potential rather than demonstrating it.

AUG 11, 2026 · JOURNAL ARTICLE

Novel Water‐Soluble, Heavy Atom‐Free Thioxanthene‐Fused Naphthalimide–Polyamine Phototheranostic Conjugates

Chemmedchem

Early-stage chemical synthesis and in vitro cell-line testing of novel photosensitizer conjugates; no animal models, clinical data, or comparative efficacy trial reported.