Chemmedchem

SEP 5, 2026 · JOURNAL ARTICLE

Covalent Targeting and Thermostabilization of Oncogenic R280K and R273H Mutants p53 by Small Molecule RVJB59

Chemmedchem

In vitro mechanistic study of a small molecule binding to mutant p53 domains, with no cell-based or clinical data, raising a question about therapeutic potential rather than demonstrating it.

AUG 11, 2026 · JOURNAL ARTICLE

Novel Water‐Soluble, Heavy Atom‐Free Thioxanthene‐Fused Naphthalimide–Polyamine Phototheranostic Conjugates

Chemmedchem

Early-stage chemical synthesis and in vitro cell-line testing of novel photosensitizer conjugates; no animal models, clinical data, or comparative efficacy trial reported.