Cellular and Molecular Life Sciences

OCT 19, 2026 · JOURNAL ARTICLE

Lung cancer metabolism: a dynamic and adaptive network

Cellular and Molecular Life Sciences

Abstract Lung cancer remains the leading cause of cancer-related mortality worldwide. Although substantial progress has been made in defining the genetic, epigenetic, and molecular

OCT 17, 2026 · JOURNAL ARTICLE

Targeted RNA m5C demethylation of NFE2L2 mRNA by dCas13b-TET2 restores ferroptosis and overcomes cisplatin resistance in bladder cancer

Cellular and Molecular Life Sciences

Cisplatin-based chemotherapy remains a cornerstone for the treatment of advanced bladder cancer; however, the emergence of resistance severely limits its clinical efficacy. Ferropt

OCT 3, 2026 · JOURNAL ARTICLE

Breast cancer stem cell metabolism: metabolic plasticity and microenvironmental regulation

Cellular and Molecular Life Sciences

Breast cancer stem cells (BCSCs) are a tumorigenic cell population implicated in tumor initiation, therapeutic resistance, metastasis, and disease recurrence. Increasing evidence i

SEP 25, 2026 · JOURNAL ARTICLE

Therapeutic targeting of the SLC39A13-AS1/TCF20/RUNX1 axis inhibits glutamine metabolism and ovarian cancer progression

Cellular and Molecular Life Sciences

“Glutamine addiction” is among the key features of tumor metabolic reprogramming and is an important target for tumor therapy. Unfortunately, the mechanisms underlying the abnormal

SEP 16, 2026 · JOURNAL ARTICLE

Noncanonical function of Claudin-1 mitigates lethal endoplasmic reticulum stress to drive prostate cancer lineage plasticity and chemoresistance

Cellular and Molecular Life Sciences

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (CRPC) driven by therapy-induced lineage plasticity. While endoplasmic reticulum (

SEP 12, 2026 · JOURNAL ARTICLE

Rewriting the cancer epigenome: CRISPR technologies for DNA methylation editing

Cellular and Molecular Life Sciences

Abstract Aberrant DNA methylation is a fundamental hallmark of cancer, characterized by widespread global hypomethylation, focal hypermethylation of key regulatory regions, and ext

SEP 11, 2026 · JOURNAL ARTICLE

Obesity-related alterations in plasma metabolomics and fecal microbiota in Down syndrome Dp(16)1Yey mice

Cellular and Molecular Life Sciences

Abstract Background/objectives Individuals with Down syndrome (DS) are at increased risk of obesity and metabolic comorbidities, yet the mechanisms underlying these conditions rema

AUG 26, 2026 · JOURNAL ARTICLE

Engineered hypoimmunogenic iPSC-derived mesenchymal stromal cells secreting high levels of functional FVIII ameliorate the hemophilia A phenotype

Cellular and Molecular Life Sciences

Preclinical proof-of-concept in animal models using engineered iPSC-derived cells; lacks human efficacy data, safety follow-up, and dose-response characterization needed to support clinical translation.