SEP 15, 2026 · JOURNAL ARTICLE
ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance
Cell Reports
The mechanism underlying the role of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) in metabolic disease remains unsolved. Using a 2′3′-cyclic GMP-AMP (cGAMP)-hydrolysi