Cell Death and Disease

OCT 22, 2026 · JOURNAL ARTICLE

PITX1 safeguards epithelial identity and restrains EMT plasticity

Cell Death and Disease

Abstract Epithelial cell identity is maintained by coordinated transcriptional and epigenetic programs that preserve tissue integrity and restrain epithelial–mesenchymal transition

OCT 14, 2026 · JOURNAL ARTICLE

Targeting alanyl-tRNA synthetase 1 unlocks antitumor immunity by inducing type I interferon signaling in ovarian cancer

Cell Death and Disease

Abstract Ovarian cancer is a leading cause of gynecological cancer-related mortality, with its immunosuppressive tumor microenvironment (TME) limiting the effectiveness of immune c

OCT 5, 2026 · JOURNAL ARTICLE

BMF deficiency promotes drug-tolerant persister cell formation in ALK/ROS1-positive lung cancer

Cell Death and Disease

Abstract Non-small cell lung cancer (NSCLC) patients with anaplastic lymphoma kinase (ALK)-fusion oncogene respond remarkably well to ALK-tyrosine kinase inhibitor (ALK-TKI) therap

SEP 28, 2026 · JOURNAL ARTICLE

Targeting USP14 disrupts lipid metabolism and survival pathways in diffuse large B-cell lymphoma (DLBCL)

Cell Death and Disease

Abstract Proteasome inhibitors have transformed cancer therapy in certain settings. However, their overall effectiveness is often limited as residual proteasome function is retaine

SEP 28, 2026 · JOURNAL ARTICLE

High-fat diet activates TPI1 lactylation to promote colorectal tumorigenesis by redirecting phospholipid synthesis toward glycolysis

Cell Death and Disease

Abstract High-fat diet (HFD) is known to promote colorectal cancer (CRC) tumorigenicity. Lactate-induced protein lysine lactylation plays a critical role in the progression of mali

SEP 26, 2026 · JOURNAL ARTICLE

The TROP2 targeting antibody-drug conjugate IMMU-132 enhances the efficacy of radiation therapy for lung cancer

Cell Death and Disease

Abstract Studies suggest that the human trophoblast cell-surface antigen (TROP2) is highly expressed in most lung cancers and is associated with poor prognosis. Currently, there ar

SEP 24, 2026 · JOURNAL ARTICLE

Mitotic bypass and continued endocycling promote cancer cell survival after genotoxic chemotherapy

Cell Death and Disease

Abstract Genotoxic chemotherapies are central components of the treatment regimen for most cancers but are rarely curative. Drug-tolerant persister cells (DTPs) evade cell death du

SEP 23, 2026 · JOURNAL ARTICLE

Oncogenic and immunomodulatory functions of SUV420H1 in HPV-negative head and neck squamous cell carcinoma

Cell Death and Disease

Abstract Despite the advent of immunotherapy, human-papilloma-virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) carries a high morbidity and mortality rate, thus n