Cell Communication and Signaling

OCT 23, 2026 · JOURNAL ARTICLE

Tumor-intrinsic RNF128 drives a non-inflamed microenvironment and immune checkpoint blockade resistance in bladder cancer

Cell Communication and Signaling

Immune checkpoint blockade (ICB), particularly anti-PD-1/PD-L1 therapy, has emerged as an important treatment option for bladder cancer (BLCA). However, a substantial proportion of

OCT 21, 2026 · JOURNAL ARTICLE

Ginsenoside Rg3 targets Glut1 acetylation to restrain immunosuppressive TAM polarization and potentiate anti-PD-1 therapy in colorectal cancer

Cell Communication and Signaling

Tumor-associated macrophages (TAMs) are the most abundant infiltrating immune cells in tumors and contribute to the formation of an immunosuppressive niche. Ginsenoside Rg3, a trit

OCT 20, 2026 · JOURNAL ARTICLE

MregDCs preferentially associate with regulatory T cells in the pancreatic tumor microenvironment

Cell Communication and Signaling

Two major, contradictory forces act simultaneously on immune cells in the tumor microenvironment (TME): one enhances the immune response following the identification of danger, whi

OCT 14, 2026 · JOURNAL ARTICLE

Mechanistic insights into neutrophil extracellular traps with emphasis on neurological diseases

Cell Communication and Signaling

Neutrophil extracellular traps (NETs) are web-like structures released by neutrophils, consisting of a DNA backbone embedded with histones and granular enzymes. Initially identifie

OCT 14, 2026 · JOURNAL ARTICLE

The ACOD1-itaconate axis in inflammation and cancer: immune regulation, context-dependent functions, and therapeutic challenges

Cell Communication and Signaling

Abstract Immunometabolism has emerged as a central framework for understanding how metabolic pathways regulate immune cell function and inflammatory responses. Among the metabolic

OCT 12, 2026 · JOURNAL ARTICLE

Chaperone-mediated autophagy as a context-resolved proteostatic decision node in breast cancer

Cell Communication and Signaling

Therapy resistance, metastatic relapse, and immune evasion are major contributors to breast cancer–related mortality; however, the proteostatic systems that support phenotypic plas

OCT 9, 2026 · JOURNAL ARTICLE

Emerging roles of mitochondria in cancer biology: mechanisms and therapeutic targeting

Cell Communication and Signaling

Abstract Cancer remains a leading cause of global mortality, with increasing incidence and limited therapeutic options for advanced-stage disease. Accumulating evidence indicates t

OCT 5, 2026 · JOURNAL ARTICLE

Lipid metabolic reprogramming in cancer: bidirectional crosstalk with epigenetic and post-translational regulation in tumor progression and therapeutic adaptation

Cell Communication and Signaling

Lipid metabolic reprogramming is increasingly recognized as a core adaptive feature of cancer, extending well beyond the passive fulfillment of lipid demand during rapid proliferat