Source

Cancer Research

3 developments in the corpus

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Everything in the corpus, newest first.

SEP 8, 2026 · JOURNAL ARTICLE

Targeting Both Oncogenic Signaling and Dependence Receptor Function is Required to Fully Suppress MET Exon 14 Skipping-Driven tumorigenesis

Cancer Research

Mechanistic study using genome editing and mouse models to propose a novel oncogenic mechanism; lacks clinical trial data or human efficacy evidence for therapeutic translation.

Hypothesis-GeneratingAgathe Laratte Sonia Paget Rémi Tellier

Study details

DesignMechanistic study with genome editing and m…

InterventionGenome editing to remove caspase cleavage s…

ComparatorIndividual mutations of caspase or CBL site…

SEP 8, 2026 · JOURNAL ARTICLE

Extracellular Matrix Remodeling in Tumors: Forces Beyond Fibroblasts

Cancer Research

A narrative review article proposing a conceptual framework that challenges the fibroblast-centric model of ECM remodeling; raises questions about non-fibroblast stromal contributions rather than testing or confirming a specific empirical claim.

Hypothesis-GeneratingSonal Srivastava Andrew C. Dudley Cancer Cells and Metastasis

AUG 11, 2026 · JOURNAL ARTICLE

Spatial Profiling Reveals Immune Escape Pathways and Therapeutic Vulnerabilities in Prostate Cancer Bone Metastases

Cancer Research

Spatial profiling study identifying mechanistic associations between immune markers and bone metastasis outcomes, but without experimental validation, clinical trial evidence, or causal intervention data to support practice change.

Hypothesis-GeneratingProstate Cancer Treatment and Research Thomas B Chadwick Birunthi Niranjan

Study details

DesignSpatial single-cell profiling with digital…

InterventionSpatial single-cell and digital spatial pro…