Cancer Research

OCT 15, 2026 · JOURNAL ARTICLE

Antiviral T cells doing double-duty to fight cancer

Cancer Research

Abstract The exquisite antigen specificity of T cells is one foundation of modern cancer immunotherapy. The therapeutic efficacy of checkpoint blockade, cancer vaccines, and engine

OCT 14, 2026 · JOURNAL ARTICLE

ARID2 Loss Reprograms the Kynurenine-AhR Pathway to Restore Antitumor Immunity in CTNNB1-Mutant Hepatocellular Carcinoma

Cancer Research

Abstract Hepatocellular carcinoma (HCC) driven by gain-of-function mutations in CTNNB1 (CTNNB1GOF) that stabilize β-catenin exhibits a profoundly immunosuppressive tumor microenvir

OCT 9, 2026 · JOURNAL ARTICLE

INSR Armoring Protects CAR-NK and CAR-T Cells Against Tumor Stroma-Induced CAR Shedding by Maintaining Cholesterol Homeostasis

Cancer Research

While chimeric antigen receptor (CAR)-engineered T and NK cell therapies have revolutionized hematological malignancy treatment, translating this success to solid tumors remains a

OCT 6, 2026 · JOURNAL ARTICLE

KDM6 Histone Demethylases Tune Pancreatic Cancer Plasticity

Cancer Research

Aberrant epigenetic regulation is a central driver of tumorigenesis, and the reversibility of epigenetic modifications underscores their potential as therapeutic targets. Epigeneti

OCT 5, 2026 · JOURNAL ARTICLE

Targeting SLC38A5 Overcomes αPD-1 Immunotherapy Resistance by Alleviating Glutamine Competition Between Glioblastoma Cells and T Cells

Cancer Research

Abstract Despite the clinical success of programmed cell death protein 1 (PD-1) checkpoint blockade in many cancer types, its efficacy in glioblastoma remains notably limited, unde

OCT 2, 2026 · JOURNAL ARTICLE

Targeting Distinct Cell Cycle Nodes Overcomes RAS Inhibitor Resistance

Cancer Research

Activating mutations in KRAS drive pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer (NSCLC). Although mutant-selective KRAS inhibitors and pan-RAS inhibitors

SEP 24, 2026 · JOURNAL ARTICLE

A Machine Learning Framework Enables Supervised Treatment Response Prediction from Tumor Transcriptomics across Cancer Types

Cancer Research

Abstract Precision oncology aims to guide treatment decisions using biomarkers. While DNA-based panels are increasingly applied, RNA transcriptomics remain underused due to limited

SEP 21, 2026 · JOURNAL ARTICLE

Senolytic Interventions Enhance the Anti-metastatic Activity of Chemotherapy in Prostate Cancer

Cancer Research

Abstract Cellular senescence is a common outcome of cytostatic and cytotoxic cancer therapies. While in some contexts therapy-induced senescence can drive tumor growth suppression