Cancer Immunology Immunotherapy

OCT 17, 2026 · JOURNAL ARTICLE

GSDMB synergizes anti-PD-1 efficacy via Sema7a-mediated CD8+ T Cell infiltration in bladder cancer

Cancer Immunology Immunotherapy

Gasdermin B (GSDMB) is highly expressed in bladder cancer (BLCA) and has been implicated in anti-tumor immunity, yet its functional role and underlying mechanisms in enhancing the

OCT 13, 2026 · JOURNAL ARTICLE

High-dose vitamin C augments LPS/IFN-γ-induced M1 macrophage polarization through JAK2-STAT1 activation and promotes anti-PD-1 efficacy in pancreatic cancer

Cancer Immunology Immunotherapy

Abstract High-dose vitamin C (HDVC) exhibits antitumor and immunomodulatory properties and may enhance the efficacy of immune checkpoint inhibitors (ICIs); however, its ability to

OCT 5, 2026 · JOURNAL ARTICLE

N-methyl-D-aspartate (NMDA) ion channels drive calcium-dependent myeloid cell reprogramming to shape cancer immunity and immunotherapy

Cancer Immunology Immunotherapy

The field of immunometabolism has highlighted the importance of metabolic signals in regulating immune responses. Various classes of ion channels act as sensors of these metabolic

OCT 2, 2026 · JOURNAL ARTICLE

Regulatory B cells and the microbiome: implications for checkpoint blockade therapy in cancer

Cancer Immunology Immunotherapy

Abstract Regulatory B cells (Bregs) restrain effector immunity through interleukin-10 (IL-10), IL-35, and transforming growth factor beta (TGF-β), and their induction depends on si

OCT 1, 2026 · JOURNAL ARTICLE

Transcription factor RBPJ improves the efficacy of PD-1/PD-L1-based therapies in non-small cell lung cancer by expanding CD8+ tissue-resident memory T cells

Cancer Immunology Immunotherapy

Tissue-resident memory T cells (Trm) are crucial local sentinels in cancer immunity; yet, their functional diversity and the role in non-small cell lung cancer (NSCLC) immune check

SEP 24, 2026 · JOURNAL ARTICLE

Revisiting human circulating γδ T cells: developmental insights and manufacturing challenges for cancer immunotherapy

Cancer Immunology Immunotherapy

γδ T cells have emerged as promising candidates for adoptive cell immunotherapy due to their major histocompatibility complex-independent tumor recognition, rapid effector response

SEP 20, 2026 · JOURNAL ARTICLE

Myeloid-derived suppressor cells confer stemness to esophageal cancer cells through the HNF1A/CXCL1 signaling axis

Cancer Immunology Immunotherapy

Abstract Our previous work established that myeloid-derived suppressor cells (MDSCs) were abundant in human esophageal squamous cell carcinoma (ESCC) and correlated with adverse pr

SEP 18, 2026 · JOURNAL ARTICLE

Personalized neoantigen vaccine platform and longitudinal tracking of vaccine-related clonotypes enable the identification of tumor-specific TCRs

Cancer Immunology Immunotherapy

Abstract Effective immunotherapeutic strategies for high-grade serous ovarian cancer (HGSOC) remain limited despite evidence of tumor immunogenicity. Here, we report the longitudin