Cancer Discovery

AUG 17, 2026 · JOURNAL ARTICLE

Gut Microbiome Metabolism Links High Fat Diets to Immunotherapy Efficacy

Cancer Discovery

Mechanistic mouse study with human biomarker validation identifying a diet-microbiome pathway affecting ICI efficacy, but efficacy outcomes are limited to preclinical models and surrogate endpoints in human patients.

AUG 14, 2026 · JOURNAL ARTICLE

First-Line HER2 ADC and Anti–PD-1 Plus Chemo Shows Efficacy in Gastric Cancer

Cancer Discovery

Single-arm phase II trial with clear efficacy signals (89.5% ORR, 13.8-month PFS) in a treatment-naïve population, but lacks a comparator and represents early-stage evidence requiring confirmation in a randomized trial.