British Journal of Pharmacology

OCT 16, 2026 · JOURNAL ARTICLE

CRISPR screens identify ACSL4 as a key regulator in macrophage activation and metabolic inflammation

British Journal of Pharmacology

Background and Purpose Pro‐inflammatory macrophages drive obesity‐associated metabolic inflammation. Identifying key regulators of their activation is crucial for new therapies. Th

OCT 2, 2026 · JOURNAL ARTICLE

Inhibition of the NR4A1‐mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity

British Journal of Pharmacology

BACKGROUND AND PURPOSE: The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proli

SEP 30, 2026 · JOURNAL ARTICLE

Direct targeting of LYN kinase by fluphenazine triggers ferroptosis to suppress lung adenocarcinoma

British Journal of Pharmacology

Abstract Background and Purpose Lung adenocarcinoma (LUAD) is an aggressive malignancy with a poor prognosis. Current therapies often cause significant side effects and result in p

SEP 29, 2026 · JOURNAL ARTICLE

Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

British Journal of Pharmacology

Abstract Background and Purpose Haemorphins are known to target G protein‐coupled receptors and their reduced serum levels were associated with diabetes and obesity. This is consis

AUG 13, 2026 · JOURNAL ARTICLE

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology

This is a mechanistic review proposing circumventricular organs as therapeutic access points for obesity drugs, rather than reporting original empirical evidence or clinical outcomes.