Ductal carcinoma in situ (DCIS) is a cancerous growth of breast duct cells that may remain indolent or progress to invasive ductal carcinoma (IDC). As screening rates increase, the
Breast cancer is a highly heterogeneous disease shaped by dynamic interactions between malignant cells, immune infiltrates, stromal compartments, and the extracellular matrix. Amon
Breast cancer lung metastasis remains a major determinant of therapeutic resistance and cancer-associated mortality, arising from the coordinated interplay between tumor cell plast
Breast cancer metastasis remains the leading cause of disease-related mortality, highlighting the need for strategies that can intercept circulating tumor cells, suppress micrometa
There is an ongoing need for first-line (1L) chemotherapies for metastatic HER2-negative breast cancer. This study evaluated the efficacy and safety profile of the dose-expansion p
Mechanistic discovery study using multi-omics and cell-based experiments identifying a putative pathway in brain metastasis, without clinical outcome data or Phase 2+ validation in patients.
Comprehensive multi-omics analysis identifying CD39-associated immunoregulatory mechanisms linked to immunotherapy resistance in TNBC, with independent validation and prognostic association, but lacking prospective clinical trial data or intervention outcomes.
Large prospective cohort study with detailed pre-diagnostic risk factor assessment and breast density measurement in a UK screening population, yielding clear odds ratios for interval cancer risk across multiple independent variables.