Biomolecules

OCT 20, 2026 · JOURNAL ARTICLE

Protein Lysine Lactylation in DNA Damage Response: Regulatory Mechanisms and Emerging Functions

Biomolecules

Genomic DNA is constantly exposed to endogenous and exogenous stresses that can cause different types of DNA damage. DNA double-strand breaks (DSBs) are among the most damaging for

OCT 19, 2026 · JOURNAL ARTICLE

GPCRs as Partners of LGR5 Cancer Stem Cells: Opportunities and Challenges

Biomolecules

Hierarchical organization transpires within a tumor. It is appreciated that cancer stem cells (CSCs) are the cornerstone primary cells of such assemblies, fueled by molecular mecha

OCT 14, 2026 · JOURNAL ARTICLE

The Effect of Cannabidiol on the Viability and Anticancer Properties of Human NK Cells: Consequences for Therapies

Biomolecules

The palliative and anti-cancer properties of CBD are attracting increasing attention. We have examined the dose-dependent effects of CBD on the viability and antitumor properties o

OCT 8, 2026 · JOURNAL ARTICLE

Epigenetic Memory in Human Diseases: Acquired Chromatin States as Targetable Drivers of Disease Evolution

Biomolecules

Clinical heterogeneity remains a major challenge across human diseases, where patients with similar genetic backgrounds frequently exhibit striking differences in disease progressi

SEP 30, 2026 · JOURNAL ARTICLE

Drug–Drug Conjugates as Intelligent Preclinical Platforms for Targeted Cancer Therapy

Biomolecules

Drug–drug conjugates (DDCs), in which two active pharmaceutical ingredients (APIs) are linked covalently within a single molecular structure to produce a synergistic therapeutic ef

SEP 21, 2026 · JOURNAL ARTICLE

Metabolic Vulnerability and Regenerative Failure of the External Urethral Sphincter: A Ferroptosis-Associated Framework for Stress Urinary Incontinence

Biomolecules

Stress urinary incontinence (SUI) has long been understood as a structural failure of pelvic floor support. While this view explains acute anatomical damage, it offers little insig

SEP 21, 2026 · JOURNAL ARTICLE

Silymarin and Zinc Oxide Nanoparticles Attenuate Experimental Colon Cancer in Rats Through Crosstalk of miR-192 and β-Catenin Pathways

Biomolecules

Colon cancer (CC) is a leading cause of cancer-related mortality globally. Although chemotherapy remains the primary treatment, its toxicity and drug resistance highlight the need

SEP 10, 2026 · JOURNAL ARTICLE

Panduratin A Induces Caspase-Dependent Apoptosis and G1-Associated Cell-Cycle Arrest and Enhances TNF-α-Associated Cytotoxicity in NSCLC Cells

Biomolecules

In vitro mechanistic study in two cell lines showing PA-induced apoptosis and cell-cycle arrest; no animal models, clinical outcomes, or quantified effect sizes reported; authors themselves call for further validation in more disease-relevant models.