Biomaterials

AUG 15, 2026 · JOURNAL ARTICLE

Oligomerized flavonoid nanointerfaces regulate gastrointestinal nutrient flux and metabolic inflammation.

Biomaterials

Oral strategies for obesity and its associated metabolic dysfunction rarely coordinate nutrient digestion, microbial ecology, barrier integrity and low-grade inflammation within th

JUL 27, 2026 · JOURNAL ARTICLE

Bioactive molecule-derived covalent organic frameworks as biocompatible scaffolds for targeted AKR1B10 inhibition in alcoholic liver disease.

Biomaterials

This is a preclinical study combining transcriptomic analysis, virtual screening, and chemical synthesis followed by testing in animal models, raising mechanistic questions about AKR1B10 and COF scaffolds rather than establishing clinical efficacy.

JUL 9, 2026 · JOURNAL ARTICLE

Functional characterization of obesity using advanced 3D in vitro adipose tissue models.

Biomaterials

This is a narrative review of in vitro methodology and mechanistic platforms, not a primary research study with empirical results or clinical outcomes.

JUL 7, 2026 · JOURNAL ARTICLE

Lymph node-targeted mRNA delivery of fine-tuned peptide-nanocomplexes for SARS-CoV-2 Vaccination.

Biomaterials

Preclinical mouse study demonstrates a novel peptide-nanocomplex delivery system with improved lymph node targeting and prolonged antigen expression compared to lipid nanoparticles, with comparable neutralizing antibody responses and superior CD8+ T cell responses, but lacks human data and clinical validation.

MAY 23, 2026 · JOURNAL ARTICLE

Dual-functional poly(disulfide) enables "Once-and-for-all" atherosclerosis therapy via precision hepatocyte base editing.

Biomaterials

Single-arm preclinical study in mouse atherosclerosis model demonstrating proof-of-concept for a novel delivery approach; lacks human data, comparator arm, and quantified effect sizes.