Biology Direct

OCT 11, 2026 · JOURNAL ARTICLE

HLA-DMA depletion suppresses malignant glioma phenotypes and murine H2-DMa knockdown enhances the response to anti-PD-1 therapy

Biology Direct

Glioblastoma (GBM) exhibits poor responsiveness to immune checkpoint blockade, largely due to an immunosuppressive tumor immune microenvironment. Tumor-associated macrophage (TAM)

OCT 9, 2026 · JOURNAL ARTICLE

Cancer-associated fibroblast-derived miR-486-3p suppresses bladder cancer by targeting the HER-2/MDK-NCL axis

Biology Direct

Cancer-associated fibroblasts (CAFs) are key stromal components of the tumor microenvironment (TME), but their potential to deliver the tumor-suppressive signals remains unclear. H

OCT 9, 2026 · JOURNAL ARTICLE

Data-driven identification of small molecules inducing brown adipocyte activation and differentiation

Biology Direct

Promoting the recruitment and function of human brown adipose tissue (BAT) holds significant promise for preventing and treating obesity and related metabolic complications. While

SEP 19, 2026 · JOURNAL ARTICLE

Plin5 alleviates endoplasmic reticulum stress to promote white adipose tissue remodeling

Biology Direct

Obesity is characterized by impaired white adipose tissue (WAT) remodeling, dysregulated lipid metabolism, and chronic endoplasmic reticulum (ER) stress. Perilipin 5 (Plin5), a lip

SEP 10, 2026 · JOURNAL ARTICLE

Ciprofol induces ferroptosis and enhances anti-PD-1 efficacy via USP1-mediated GPX4 ubiquitination in hepatocellular carcinoma

Biology Direct

Mechanistic preclinical study with in vitro and mouse models showing ciprofol induces ferroptosis and enhances anti-PD-1 efficacy in HCC; no human clinical data or phase 1 trial reported, limiting evidence strength despite sound experimental design.

AUG 11, 2026 · JOURNAL ARTICLE

An ICAM1⁺ inflammatory fibroblast state in atrial fibrillation and metabolic-stress-associated atrial remodeling

Biology Direct

Single-centre mechanistic study combining human transcriptomics reanalysis with mouse disease modelling and in vitro fibroblast manipulation; identifies a putative fibroblast state and pathway associations but lacks clinical endpoints and acknowledges need for further work to establish causality and clinical relevance.