Bioconjugate Chemistry

OCT 9, 2026 · JOURNAL ARTICLE

Facile Gram-Scale Solution Phase Synthesis of a Universal Cathepsin B-Cleavable Antibody-Drug Conjugate Linker

Bioconjugate Chemistry

Abstract Antibody drug conjugates (ADCs) are a key therapy in the cancer treatment arsenal. Critical to the success of the ADC is the release of the drug cargo at the desired site,

OCT 8, 2026 · JOURNAL ARTICLE

Ultrasound-Triggered Site-Specific Chemistry Redefines Precision Oncology

Bioconjugate Chemistry

Abstract Ultrasound-triggered site-specific molecular chemistry has emerged as a transformative strategy for cancer therapy, yet precise spatiotemporal control of their activity re

SEP 23, 2026 · JOURNAL ARTICLE

Bone-Targeting Antibodies for Skeletal Precision Therapy

Bioconjugate Chemistry

Abstract Therapeutic antibodies have transformed the treatment of cancer, inflammation, infection, and disorders of bone biology by recognizing disease-associated molecular targets

SEP 21, 2026 · JOURNAL ARTICLE

Macrophage-Targeted Quantum Dots with Short-Wave Infrared Emission for In Vivo Breast Cancer Imaging

Bioconjugate Chemistry

Abstract In vivo characterization and visualization of tumors often relies on radioactive tracers and expensive, complex equipment, which limits the frequency of analysis, throughp

AUG 18, 2026 · JOURNAL ARTICLE

InterfaciallyEngineered Hafnium-Doped Hollow PrussianBlue Nanoreactors for Hypoxia-Relieved Synergistic Radio-Chemo-PhotothermalTherapy

Bioconjugate Chemistry

This is a preclinical in vivo proof-of-concept study of a novel nanoparticle platform in mice; it demonstrates mechanistic feasibility but lacks clinical translation, efficacy comparators, or human data needed to guide clinical practice.

AUG 10, 2026 · JOURNAL ARTICLE

DifferentialChemoselectivity of Homobifunctionaland Monofunctional Maleimide Reagents for Bioconjugation

Bioconjugate Chemistry

An exploratory chemical characterization study demonstrating differential reactivity patterns of maleimide reagents; raises mechanistic questions about linker valency but does not test clinical or therapeutic outcomes.