BMC Medicine

OCT 21, 2026 · JOURNAL ARTICLE

Adjuvant EGFR-TKI therapy in completely resected non–small cell lung cancer with major uncommon EGFR mutations: a real-world study

BMC Medicine

The clinical benefit of adjuvant epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with completely resected non-small cell lung cancer (NSCLC) h

OCT 19, 2026 · JOURNAL ARTICLE

Comparative effectiveness of first-/second-generation EGFR-TKI combination therapy versus third-generation EGFR-TKI monotherapy in untreated locally advanced or metastatic EGFR-mutant NSCLC: a real-world, retrospective study in China

BMC Medicine

Third-generation (3G) epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are recommended first-line options for advanced EGFR -mutant non-small cell lung can

OCT 11, 2026 · JOURNAL ARTICLE

The cardiovascular–liver–metabolic syndemic and mortality and life expectancy: two prospective cohort studies

BMC Medicine

Cardiovascular disease (CVD), metabolic dysfunction–associated steatotic liver disease (MASLD), type 2 diabetes mellitus (T2DM), and obesity frequently coexist and share overlappin

OCT 6, 2026 · JOURNAL ARTICLE

Targeting food addiction through an intensive energy-reduced Mediterranean diet lifestyle intervention: evidence from the 3-year PREDIMED-plus trial

BMC Medicine

Food addiction (FA) has been proposed as a behavioural phenotype linked to obesity, potentially influencing adherence and response to lifestyle interventions. Its role within long-

OCT 5, 2026 · JOURNAL ARTICLE

Determinants of failure of midazolam monotherapy during continuous deep sedation until death: evidence from a French cohort in a palliative care unit

BMC Medicine

Abstract Background Continuous deep sedation until death (CDSUD) is a legally regulated practice in France relying primarily on midazolam as first-line therapy. However, additional

SEP 26, 2026 · JOURNAL ARTICLE

Therapy-induced senescent cancer-associated fibroblasts in cervical cancer: Mechanisms of treatment resistance and therapeutic opportunities

BMC Medicine

Abstract Background Cervical cancer remains a major global health burden, and concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced disease. However, a

SEP 18, 2026 · JOURNAL ARTICLE

Brain radiotherapy synergizes with first-line, third-generation EGFR-TKIs in patients with EGFR-mutant NSCLC and treatment-naïve brain metastases: a multicenter real-world study

BMC Medicine

First-line third generation (3rd-gen) epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are the standard of care for patients with EGFR-mutant advanced non-sm

SEP 18, 2026 · JOURNAL ARTICLE

A structural cardiac pathway mediates the risk of ischemic heart disease from TyG-related indices: A prospective cohort study

BMC Medicine

The triglyceride-glucose (TyG) index and its derivatives are surrogate markers of insulin resistance and are closely associated with cardiovascular risk. However, whether and to wh