AUG 17, 2026 · JOURNAL ARTICLE
Transcriptome-based macroautophagy and chaperone-mediated autophagy states reveal context-dependent vulnerabilities across human cancers
Autophagy
A sound but single-cancer-model mechanistic study with cell-line and xenograft data, identifying a druggable autophagy-CMA pathway in KRAS-mutant pancreatic cancer; needs confirmation in clinical trials.
Reported
Primary modelsKRAS-mutant pancreatic cancer cells and PAN…
Lead compoundAll-trans retinoic acid (ATRA)
Key regulatory proteins modulatedLAMP2A, TFEB, ULK1, SEMA6D