Autophagy

OCT 13, 2026 · JOURNAL ARTICLE

Innate immune signaling relays environmental cues to mitophagy for metabolic adaptation to obesity

Autophagy

The mechanisms by which pancreatic β cells sense and communicate environmental cues to mitochondria to maintain insulin secretion remain poorly understood. We identified that β cel

AUG 17, 2026 · JOURNAL ARTICLE

Transcriptome-based macroautophagy and chaperone-mediated autophagy states reveal context-dependent vulnerabilities across human cancers

Autophagy

A sound but single-cancer-model mechanistic study with cell-line and xenograft data, identifying a druggable autophagy-CMA pathway in KRAS-mutant pancreatic cancer; needs confirmation in clinical trials.