JUL 13, 2026 · JOURNAL ARTICLE
Transciptomic Profiling of CRISPR-Cas9 Mediated LEF1 Knockout in Chronic Lymphocytic Leukemia: Revealing Compensatory Survical Pathways
Asian Pacific Journal of Cancer Biology
This is a bioinformatic analysis of gene expression data identifying potential compensatory pathways after LEF1 disruption; it raises mechanistic questions rather than testing them functionally or clinically, and requires experimental validation.
Reported
LEF1 Log2 fold-change-6.22
SLC3A2 Log2 fold-change+3.59
JUN Log2 fold-change+3.10