A retrospective single-centre cohort study identifies BMI and dyslipidemia as associations with improved PFS in anti-PD-1-treated CRC, supported by exploratory lipidomic profiling, but lacks a control arm and prospective design to establish causation or clinical utility.
Non-interventional pilot study in 20 patients without a control arm, reporting motor and pain improvements with pridinol added to botulinum toxin, but lacking comparative evidence and power to support clinical decision-making.
Single-center retrospective study with clear associations between elevated homocysteine and renal pathology in IgAN, but modest discriminative ability (AUC 0.756) and attenuation after adjustment for renal function limit clinical utility.
Cross-sectional observational study with modest sample size (n=115) examining associations between maternal role perception and recovery motivation in women with severe mental illness; correlational findings require replication and do not establish causation or clinical utility.
This is a published protocol for a prospective randomized controlled trial not yet completed; it describes planned methods and outcomes but reports no results, making it a hypothesis-generating document rather than evidence of efficacy.
Small single-center matched cohort study (31 per group) with retrospective design and surrogate endpoints; findings on concurrent nephropathy and renal function decline are clinically relevant but require validation in larger prospective studies.
Large, well-designed population-based case-crossover study with clear effect sizes and confidence intervals showing independent association between RBC transfusion and venous thrombosis in cancer patients after adjustment for confounders.
Retrospective cohort study of 216 newly diagnosed AL amyloidosis patients demonstrating that limited dexamethasone (≤3 months) achieves similar overall response rates with faster deep hematologic response and reduced toxicity compared to prolonged exposure, with multivariable adjustment for confounding.