AUG 17, 2026 · JOURNAL ARTICLE
Insulin-Regulated Actin Dynamics is Disrupted in a Human Keratinocyte Model of Hailey Hailey Disease
American Journal of Physiology-cell Physiology
In vitro mechanistic study in immortalized keratinocytes using CRISPR knockouts, demonstrating pathway defects and proof-of-concept rescue; lacks in vivo validation or clinical outcome data required for stronger evidence.
Study details
DesignIn vitro cell model study with CRISPR/Cas9…
InterventionCRISPR/Cas9-mediated ATP2C1 knockout (singl…
ComparatorWild-type immortalized human hTERT keratino…