Acs Chemical Biology

OCT 3, 2026 · JOURNAL ARTICLE

Ebselen Inactivates Essential Mycoplasmopsis bovis Proteins

Acs Chemical Biology

Abstract Mycoplasmopsis bovis contributes to a variety of infectious diseases in cattle that limit meat and milk production, motivating significant antimicrobial use to prevent ani

SEP 23, 2026 · JOURNAL ARTICLE

Toll-like Receptor 2 Recognition of Microbiota Lipoproteins and Lipids in Immunity and Therapy

Acs Chemical Biology

Abstract Toll-like receptor 2 (TLR2) recognizes a remarkably diverse range of microbial molecules and plays central roles in host defense, immune homeostasis, and cancer immunother

SEP 11, 2026 · JOURNAL ARTICLE

Ultramutagenesis through Combined Msh2 Depletion and Proofreading-Deficient DNA Polymerase ε Expression Enhances Small-Molecule Target Identification in Forward Genetic Screens

Acs Chemical Biology

DNA mismatch repair (MMR) deficiency has been widely utilized in forward genetic screens to identify drug resistance mutations and elucidate the mechanisms of action of cytotoxic s

SEP 7, 2026 · JOURNAL ARTICLE

Exploiting Acquired Drug Resistance in Pancreatic Cancer through Selective Covalent Targeting of MAP2K4/7

Acs Chemical Biology

Mechanistic preclinical study proposing a resistance-escape strategy in cell models; no clinical data, no human subjects, and no comparative efficacy trial to support practice change.