Acs Applied Materials & Interfaces

OCT 23, 2026 · JOURNAL ARTICLE

Integrated Droplet Microfluidic Platform for Single-Spheroid Photothermal Nanotherapy and Morphology-Driven Response Prediction

Acs Applied Materials & Interfaces

Abstract Photothermal therapy (PTT) is a promising cancer treatment modality, but its evaluation remains limited by the lack of physiologically relevant and quantitatively controll

OCT 19, 2026 · JOURNAL ARTICLE

Cascade-Catalytic MnO2 Nanoreactor Amplifies Oxidative Stress and Activates cGAS–STING Pathway To Remodel the Immunosuppressive Microenvironment of Triple-Negative Breast Cancer

Acs Applied Materials & Interfaces

Abstract Triple-negative breast cancer (TNBC) is characterized by a highly immunosuppressive tumor microenvironment, which severely limits the therapeutic efficacy of current immun

OCT 19, 2026 · JOURNAL ARTICLE

Dual-Responsive Nanoplatform: In Situ Self-Assembly Enables OFF-to-ON Photothermal Switching for Multimodal Synergistic Tumor Therapy

Acs Applied Materials & Interfaces

Abstract Photothermal therapy has attracted extensive attention in tumor treatment owing to its spatiotemporal controllability and noninvasiveness. However, the nonselective “alway

OCT 16, 2026 · JOURNAL ARTICLE

Sequential Dual Nanoparticle Approach for Extracellular Matrix Remodeling and Targeted Chemotherapy through Liposome–Exosome Hybridization in Pancreatic Cancer

Acs Applied Materials & Interfaces

Abstract Pancreatic cancer remains one of the most aggressive and treatment-resistant malignancies, with a poor prognosis and limited response to conventional therapies. Although l

OCT 16, 2026 · JOURNAL ARTICLE

High-Throughput Screening of a Lipid Nanoparticle (LNP) Library Identifies Lead Formulations for CRISPR-Cas9 Ribonucleoprotein Delivery and Gene Editing

Acs Applied Materials & Interfaces

Abstract Delivery of CRISPR-Cas9 ribonucleoprotein (RNP) using synthetic materials can bypass the host translational machinery and limit the duration of genomic exposure, minimizin

OCT 14, 2026 · JOURNAL ARTICLE

PROTAC-Loaded Nanoparticles Induce a “ROS Storm” through Targeted Degradation of GPX4 in Combination with a Mild Photothermal/Fenton-like Reaction for the Treatment of Triple-Negative Breast Cancer

Acs Applied Materials & Interfaces

Abstract Proteolysis-targeting chimeras (PROTACs) are a promising therapeutic approach for degrading disease-causing proteins. However, they often encounter limitations in in vivo

OCT 13, 2026 · JOURNAL ARTICLE

Folic Acid-Functionalized Liposomes Co-Loaded with Doxorubicin and Indocyanine Green for Combined Chemophotothermal Therapy of Cervical Cancer

Acs Applied Materials & Interfaces

Abstract The development of multimodal combined treatment strategies employing nanomedicine delivery systems effectively addresses the drawbacks of traditional tumor treatment, suc

OCT 12, 2026 · JOURNAL ARTICLE

Next-Generation Autocatalysis-Integrated Antibody-Bioorthogonal Catalyst Conjugates for Amplified Cell-Surface Antigen Imaging and Targeted In Situ Prodrug Activation

Acs Applied Materials & Interfaces

Abstract Immunoassays and antibody–drug conjugates (ADCs) rely on specific antigen–antibody recognition for biomarker detection and targeted cancer therapy; however, their practica