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Life sciences · Observational Study
ClinicalTrials.gov · September 28, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT06477484). This is a study registration, not published results. Lead sponsor: Peking University First Hospital. Recruitment status: COMPLETED. Study type: OBSERVATIONAL. Enrollment: 180 participants (ACTUAL). Conditions: Alzheimer's Disease, Blood Biomarkers. Interventions: DIAGNOSTIC_TEST: Blood biomarker. Primary outcome measures: Evaluate the diagnostic accuracy of blood biomarkers of Aβ42, Aβ40, Aβ42/Aβ40, P-Tau181, P-Tau217, GFAP and NfL. , 2 years. Brief summary: The goal of this observational study is to estimate the screen performance of blood biomarkers of interest (Aβ40 and Aβ42, P-Tau181, P-Tau217, GFAP and NfL) in patients with Alzheimer's disease (AD), mild cognitive impairment due to AD, and cognitively normal individuals. The main questions it aims to answer are: * to identify core blood biomarker suitable for early screening of AD. * to establish a comprehensive model for the early identification of AD.