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Life sciences · Interventional Study
ClinicalTrials.gov · September 14, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT06794125). This is a study registration, not published results. Lead sponsor: Chris Goodman. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 141 participants (ESTIMATED). Conditions: Lung Cancers. Interventions: RADIATION: Hypofractionated Radiation Therapy; RADIATION: Radiation Therapy. Primary outcome measures: time to definitive quality of life deterioration or death , from enrollment until 36 months post radiotherapy. Brief summary: This is a pragmatic trial with patients randomized between standard of care palliative thoracic radiation therapy (RT) vs. hypofractionated, dose-escalated, esophageal-sparing (HD-ES) intensity modulated radiation therapy (IMRT). The investigators hypothesize that the use of advanced radiation planning techniques to optimize dose to esophagus will permit the safe delivery of a modestly dose-escalated five-fraction course of palliative radiation to intrathoracic malignancies. This approach aims to deliver higher biologically effective doses while improving toxicity when compared to conventional approaches with the goal of prolonging high-quality overall survival.